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目的 分析老年肝细胞癌患者外周血中CD161+/-T细胞群分布及其与肝细胞癌发生风险、治疗疗效的关联性。方法 纳入肝细胞癌患者86例为肝癌组，同期健康体检者86例为对照组，检测外周血中CD161+/-TT细胞群分布，分析其与肝细胞癌风险及肝动脉化疗栓塞治疗疗效的关系。结果 单因素分析显示，饮酒及CD3~+CD161~+T、CD3~+CD4~+CD161~+T、CD3~+CD8~+CD161~+T细胞群与老年罹患肝细胞癌有关(P<0.05);Logistic回归分析显示，饮酒及CD3~+CD161~+T、CD3~+CD8~+CD161~+T细胞群是老年罹患肝细胞癌的危险因素(P<0.05);受试者工作特征(ROC)曲线显示，该模型预测肝细胞癌风险的曲线下面积(AUC)为0.708,95%CI:0.630～0.785,敏感度、特异性分别为0.767、0.570;肝动脉化疗栓塞治疗后有效58例，无效28例，其中CD3~+CD4~+CD161+/-T细胞群患者疗效无统计学差异(P>0.05),CD3~+CD161+/-T、CD3~+CD8~+CD161+/-T细胞群疗效差异显著(P<0.05)。结论 CD161+/-T细胞分布差异可能与肝细胞癌发生风险有关，主要涉及CD3~+CD161+/-T、CD3~+CD8~+CD161+/-T细胞群，同时也与肝动脉化疗栓塞治疗应答情况有关。
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基本信息:
中图分类号:R735.7
引用信息:
[1]周素涛,郭娟,马科,等.外周血中CD161~(+/-)T细胞分布在老年肝细胞癌诊断及疗效评估中的应用价值[J].中国老年学杂志,2026,46(06):993-996.
基金信息:
2023年度河北省医学科学研究课题计划(20231463)