中国老年学杂志

参考文献

1 Alonaizan R,Carr C.Cardiac regeneration following myocardial infarction:the need for regeneration and a review of cardiac stromal cell populations used for transplantation[J].Biochem Soc Trans,2022;50(1):269-81.

2 Csöbönyeiová M,Beerová N,Klein M,et al.Cell-based and selected cell-free therapies for myocardial infarction:how do they compare to the current treatment options[J]?Int J Mol Sci,2022;23(18):10314.

3 Yin X,Lin L,Fang F,et al.Mechanisms and optimization strategies of paracrine exosomes from mesenchymal stem cells in ischemic heart disease[J].Stem Cells Int,2023;2023:6500831.

4 Toma C,Pittenger MF,Cahill KS,et al.Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart[J].Circulation,2002;105(1):93-8.

5 Brown C,McKee C,Bakshi S,et al.Mesenchymal stem cells:cell therapy and regeneration potential[J].J Tissue Eng Regen Med,2019;13(9):1738-55.

6 Deo D,Marchioni M,Rao P.Mesenchymal stem/stromal cells in organ transplantation[J].Pharmaceutics,2022;14(4):791.

7 Dominici M,Le Blanc K,Mueller I,et al.Minimal criteria for defining multipotent mesenchymal stromal cells.The International Society for Cellular Therapy position statement[J].Cytotherapy,2006;8(4):315-7.

8 Fu X,Liu G,Halim A,et al.Mesenchymal stem cell migration and tissue repair[J].Cells,2019;8(8):784.

9 Song N,Scholtemeijer M,Shah K.Mesenchymal stem cell immunomodulation:mechanisms and therapeutic potential[J].Trends Pharmacol Sci,2020;41(9):653-64.

10 Galipeau J,Sensébé L.Mesenchymal stromal cells:clinical challenges and therapeutic opportunities[J].Cell Stem Cell,2018;22(6):824-33.

11 Jiang L,Yang A,Li X,et al.Down-regulation of VCAM-1 in bone mesenchymal stem cells reduces inflammatory responses and apoptosis to improve cardiac function in rat with myocardial infarction[J].Int Immunopharmacol,2021;101(Pt A):108180.

12 Marinkovic G,Grauen Larsen H,Yndigegn T,et al.Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction[J].Eur Heart J,2019;40(32):2713-23.

13 Marinkovic G,Koenis DS,de Camp L,et al.S100A9 links inflammation and repair in myocardial infarction[J].Circ Res,2020;127(5):664-76.

14 Lee RH,Pulin AA,Seo MJ,et al.Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6[J].Cell Stem Cell,2009;5(1):54-63.

15 Dyer DP,Thomson JM,Hermant A,et al.TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8[J].J Immunol,2014;192(5):2177-85.

16 Zhang Z,Tian H,Yang C,et al.Mesenchymal stem cells promote the resolution of cardiac inflammation after ischemia reperfusion via enhancing efferocytosis of neutrophils[J].J Am Heart Assoc,2020;9(5):e014397.

17 Negi N,Griffin MD.Effects of mesenchymal stromal cells on regulatory T cells:current understanding and clinical relevance[J].Stem Cells,2020;38(5):596-605.

18 Wang X,Guo Z,Ding Z,et al.Inflammation,autophagy,and apoptosis after myocardial infarction[J].J Am Heart Assoc,2018;7(9):e008024.

19 Kheila M,Gorjipour F,Hosseini Gohari L,et al.Human mesenchymal stem cells derived from amniotic membrane attenuate isoproterenol(ISO)-induced myocardial injury by targeting apoptosis[J].Med J Islam Repub Iran,2021;35:82.

20 Frangogiannis NG.Cardiac fibrosis:cell biological mechanisms,molecular pathways and therapeutic opportunities[J].Mol Aspects Med,2019;65:70-99.

21 Prabhu SD,Frangogiannis NG.The biological basis for cardiac repair after myocardial infarction:from inflammation to fibrosis[J].Circ Res,2016;119(1):91-112.

22 Mias C,Lairez O,Trouche E,et al.Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction[J].Stem Cells,2009;27(11):2734-43.

23 Jin L,Zhang J,Deng Z,et al.Mesenchymal stem cells ameliorate myocardial fibrosis in diabetic cardiomyopathy via the secretion of prostaglandin E2[J].Stem Cell Res Ther,2020;11(1):122.

24 Sadat S,Gehmert S,Song YH,et al.The cardioprotective effect of mesenchymal stem cells is mediated by IGF-Ⅰ and VEGF[J].Biochem Biophys Res Commun,2007;363(3):674-9.

25 Li Q,Hou H,Li M,et al.CD73+ mesenchymal stem cells ameliorate myocardial infarction by promoting angiogenesis[J].Front Cell Dev Biol,2021;9:637239.

26 Zhao J,Li X,Hu J,et al.Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization[J].Cardiovasc Res,2019;115(7):1205-16.

27 Huang L,Yang L,Ding Y,et al.Human umbilical cord mesenchymal stem cells-derived exosomes transfers microRNA-19a to protect cardiomyocytes from acute myocardial infarction by targeting SOX6[J].Cell Cycle,2020;19(3):339-53.

28 Wang X,Zhu Y,Wu C,et al.Adipose-derived mesenchymal stem cells-derived exosomes carry microRNA-671 to alleviate myocardial infarction through inactivating the TGFBR2/Smad2 axis[J].Inflammation,2021;44(5):1815-30.

29 Wu Y,Peng W,Fang M,et al.MSCs-derived extracellular vesicles carrying miR-212-5p alleviate myocardial infarction-induced cardiac fibrosis via NLRC5/VEGF/TGF-β1/SMAD axis[J].J Cardiovasc Transl Res,2022;15(2):302-16.

30 Ning W,Li S,Yang W,et al.Blocking exosomal miRNA-153-3p derived from bone marrow mesenchymal stem cells ameliorates hypoxia-induced myocardial and microvascular damage by targeting the ANGPT1-mediated VEGF/PI3k/Akt/eNOS pathway[J].Cell Signal,2021;77:109812.

31 Yang M,Liu X,Jiang M,et al.miR-543 in human mesenchymal stem cell-derived exosomes promotes cardiac microvascular endothelial cell angiogenesis after myocardial infarction through COL4A1[J].IUBMB Life,2021;73(7):927-40.

32 Toma C,Wagner WR,Bowry S,et al.Fate of culture-expanded mesenchymal stem cells in the microvasculature:in vivo observations of cell kinetics[J].Circ Res,2009;104(3):398-402.

33 Barbash IM,Chouraqui P,Baron J,et al.Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium:feasibility,cell migration,and body distribution[J].Circulation,2003;108(7):863-8.

34 Golpanian S,El-Khorazaty J,Mendizabal A,et al.Effect of aging on human mesenchymal stem cell therapy in ischemic cardiomyopathy patients[J].J Am Coll Cardiol,2015;65(2):125-32.

35 Song HF,He S,Li SH,et al.Aged human multipotent mesenchymal stromal cells can be rejuvenated by neuron-derived neurotrophic factor and improve heart function after injury[J].JACC Basic Transl Sci,2017;2(6):702-16.

36 Dimmeler S,Vasa-Nicotera M.Aging of progenitor cells:limitation for regenerative capacity[J]?J Am Coll Cardiol,2003;42(12):2081-2.

37 Ren R,Ocampo A,Liu GH,et al.Regulation of stem cell aging by metabolism and epigenetics[J].Cell Metab,2017;26(3):460-74.

38 Zhang W,Song M,Qu J,et al.Epigenetic modifications in cardiovascular aging and diseases[J].Circ Res,2018;123(7):773-86.

39 Oshima Y,Ouchi N,Sato K,et al.Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart[J].Circulation,2008;117(24):3099-108.

40 Shimano M,Ouchi N,Nakamura K,et al.Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload[J].Proc Natl Acad Sci U S A,2011;108(43):E899-906.

41 Shen H,Cui G,Li Y,et al.Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model[J].Stem Cell Res Ther,2019;10(1):17.

42 Xiang Q,Liao Y,Chao H,et al.ISL1 overexpression enhances the survival of transplanted human mesenchymal stem cells in a murine myocardial infarction model[J].Stem Cell Res Ther,2018;9(1):51.

43 Wu R,Hu W,Chen H,et al.A novel human long noncoding RNA SCDAL promotes angiogenesis through SNF5-mediated GDF6 expression[J].Adv Sci(Weinh),2021;8(18):e2004629.

44 Wang P,Deng Z,Li A,et al.β-Catenin promotes long-term survival and angiogenesis of peripheral blood mesenchymal stem cells via the Oct4 signaling pathway[J].Exp Mol Med,2022;54(9):1434-49.

45 Colaianni G,Cinti S,Colucci S,et al.Irisin and musculoskeletal health[J].Ann N Y Acad Sci,2017;1402(1):5-9.

46 Zhang X,Hu C,Kong CY,et al.FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT[J].Cell Death Differ,2020;27(2):540-55.

47 Ouyang H,Li Q,Zhong J,et al.Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways[J].J Cell Physiol,2020;235(10):6647-59.

48 Deng J,Zhang N,Wang Y,et al.FNDC5/irisin improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells for myocardial infarction[J].Stem Cell Res Ther,2020;11(1):228.

49 Yang F,Wu R,Jiang Z,et al.Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation[J].Cell Death Dis,2018;9(5):556.

50 Cho HM,Lee KH,Shen YM,et al.Transplantation of hMSCs genome edited with LEF1 improves cardio-protective effects in myocardial infarction[J].Mol Ther Nucleic Acids,2020;19:1186-97.

51 Zhang H,Zhao C,Jiang G,et al.Apelin rejuvenates aged human mesenchymal stem cells by regulating autophagy and improves cardiac protection after infarction[J].Front Cell Dev Biol,2021;9:628463.

52 Gara E,Ong SG,Winkler J,et al.Cell-based HIF1α gene therapy reduces myocardial scar and enhances angiopoietic proteome,transcriptomic and miRNA expression in experimental chronic left ventricular dysfunction[J].Front Bioeng Biotechnol,2022;10:767985.

53 Zhang S,Zhao L,Wang J,et al.HIF-2α and Oct4 have synergistic effects on survival and myocardial repair of very small embryonic-like mesenchymal stem cells in infarcted hearts[J].Cell Death Dis,2017;8(1):e2548.

54 Covello KL,Kehler J,Yu H,et al.HIF-2alpha regulates Oct-4:effects of hypoxia on stem cell function,embryonic development,and tumor growth[J].Genes Dev,2006;20(5):557-70.

55 Feng D,Zhang L,Ding F,et al.Blocking Nox2 improves mesenchymal stem cells therapy in myocardial infarction via antagonizing oxidant and promoting survival[J].J Cell Physiol,2018;233(10):7004-15.

56 Weng CF,Wu CF,Kao SH,et al.Down-regulation of miR-34a-5p potentiates protective effect of adipose-derived mesenchymal stem cells against ischemic myocardial infarction by stimulating the expression of C1q/tumor necrosis factor-related protein-9[J].Front Physiol,2019;10:1445.

57 韩敦正，覃小洲，潘秀娣，等.凋亡诱导因子基因敲减对骨髓间充质干细胞移植治疗心肌梗死的影响[J].中国组织工程研究，2024;28:3967-73.

58 Gao X,Liang X,Liu B,et al.Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction[J].FASEB J,2023;37(12):e23294.

59 Dong J,Liu J,Wen Y,et al.Down-regulation of Lnc-CYP7A1-1 rejuvenates aged human mesenchymal stem cells to improve their efficacy for heart repair through SYNE1[J].Front Cell Dev Biol,2020;8:600304.

60 Yang YJ,Qian HY,Huang J,et al.Atorvastatin treatment improves survival and effects of implanted mesenchymal stem cells in post-infarct swine hearts[J].Eur Heart J,2008;29(12):1578-90.

61 Li N,Guo XY,Zhou J,et al.Atorvastatin pretreatment ameliorates mesenchymal stem cell migration through miR-146a/CXCR4 signaling[J].Tissue Eng Regen Med,2021;18(5):863-73.

62 Abd El-Fattah AI,Zaghloul MS,Eltablawy NA,et al.α-Lipoic acid and amlodipine/perindopril combination potentiate the therapeutic effect of mesenchymal stem cells on isoproterenol induced cardiac injury in rats[J].Biochimie,2019;156:59-68.

63 Han XJ,Li H,Liu CB,et al.Guanxin Danshen Formulation improved the effect of mesenchymal stem cells transplantation for the treatment of myocardial infarction probably via enhancing the engraftment[J].Life Sci,2019;233:116740.

64 Mustafa T,Khan I,Iqbal H,et al.Rutin and quercetagetin enhance the regeneration potential of young and aging bone marrow-derived mesenchymal stem cells in the rat infarcted myocardium[J].Mol Cell Biochem,2023;478(8):1759-70.

65 王超，杜泓森，侯季秋，等.慢性情绪应激对急性心肌梗死后骨髓c-kit+干细胞动员的影响[J].中国循环杂志，2018;33:709-13.

66 侯季秋，史金玉，安莹，等.双心方治疗冠心病心绞痛合并抑郁状态临床观察[J].河南中医，2019;39:224-7.

67 Wang C,Hou J,Du H,et al.Anti-depressive effect of Shuangxinfang on rats with acute myocardial infarction:promoting bone marrow mesenchymal stem cells mobilization and alleviating inflammatory response[J].Biomed Pharmacother,2019;111:19-30.

68 Guo E,Sun L,Chen W,et al.Young human PRP promotes the rejuvenation of aged bone marrow mesenchymal stem cells and the therapeutic effect on ischemic heart disease[J].Eur J Pharmacol,2023;950:175775.

69 Li L,Li L,Zhang Z,et al.Hypoxia promotes bone marrow-derived mesenchymal stem cell proliferation through apelin/APJ/autophagy pathway[J].Acta Biochim Biophys Sin(Shanghai),2015;47(5):362-7.

70 Liu H,Sun X,Gong X,et al.Human umbilical cord mesenchymal stem cells derived exosomes exert antiapoptosis effect via activating PI3K/Akt/mTOR pathway on H9C2 cells[J].J Cell Biochem,2019;120(9):14455-64.

71 李艳，张燕，张宁坤，等.缺氧预处理人华通胶间充质干细胞条件上清对心肌缺血再灌注损伤的作用及机制[J].中国组织工程研究，2022;26(1):5008-13.

72 张蘋，郭莹，高亚杰，等.低氧预处理人脐带间充质干细胞促进其源性外泌体对心肌梗死后心肌损伤的修复[J].中国组织工程研究，2019;23(17):2630-6.

73 张敏，娄国，付常喜.有氧运动预适应改善骨髓间充质干细胞治疗急性心肌梗死的效果[J].中国组织工程研究，2024;28(25):3988-93.

74 Memon IA,Sawa Y,Fukushima N,et al.Repair of impaired myocardium by means of implantation of engineered autologous myoblast sheets[J].J Thorac Cardiovasc Surg,2005;130(5):1333-41.

75 Sekiya N,Matsumiya G,Miyagawa S,et al.Layered implantation of myoblast sheets attenuates adverse cardiac remodeling of the infarcted heart[J].J Thorac Cardiovasc Surg,2009;138(4):985-93.

76 Choi A,Kim H,Han H,et al.Sutureless transplantation ofin vivopriming human mesenchymal stem cell sheet promotes the therapeutic potential for cardiac repair[J].Biofabrication,2022;15(1):015012.

77 Sekula-Stryjewska M,Noga S,Dzwigońska M,et al. Graphene-based materials enhance cardiomyogenic and angiogenic differentiation capacity of human mesenchymal stem cells in vitro-focus on cardiac tissue regeneration[J].Mater Sci Eng C Mater Biol Appl,2021;119:111614.

78 Davis KA,Peng H,Chelvarajan L,et al.Increased yield of gelatin coated therapeutic cells through cholesterol insertion[J].J Biomed Mater Res A,2021;109(3):326-35.

79 Gottipati A,Chelvarajan L,Peng H,et al.Gelatin based polymer cell coating improves bone marrow-derived cell retention in the heart after myocardial infarction[J].Stem Cell Rev Rep,2019;15(3):404-14.

80 Davis KA,Wu PJ,Cahall CF,et al.Coatings on mammalian cells:interfacing cells with their environment[J].J Biol Eng,2019;13:5.

81 Peng H,Chelvarajan L,Donahue R,et al.Polymer cell surface coating enhances mesenchymal stem cell retention and cardiac protection[J].ACS Appl Bio Mater,2021;4(2):1655-67.

82 Lyu Y,Xie J,Liu Y,et al.Injectable hyaluronic acid hydrogel loaded with functionalized human mesenchymal stem cell aggregates for repairing infarcted myocardium[J].ACS Biomater Sci Eng,2020;6(12):6926-37.

83 Luo W,Gong Y,Qiu F,et al.NGF nanoparticles enhance the potency of transplanted human umbilical cord mesenchymal stem cells for myocardial repair[J].Am J Physiol Heart Circ Physiol,2021;320(5):H1959-74.

84 Sun Z,Cai Y,Chen Y,et al.Ultrasound-targeted microbubble destruction promotes PDGF-primed bone mesenchymal stem cell transplantation for myocardial protection in acute myocardial infarction in rats[J].J Nanobiotechnol,2023;21(1):481.

85 Zhang CS,Shao K,Liu CW,et al.Hypoxic preconditioning BMSCs-exosomes inhibit cardiomyocyte apoptosis after acute myocardial infarction by upregulating microRNA-24[J].Eur Rev Med Pharmacol Sci,2019;23(15):6691-9.

86 Gao W,He R,Ren J,et al.Exosomal HMGB1 derived from hypoxia-conditioned bone marrow mesenchymal stem cells increases angiogenesis via the JNK/HIF-1α pathway[J].FEBS Open Bio,2021;11(5):1364-73.

87 Sun J,Shen H,Shao L,et al.HIF-1α overexpression in mesenchymal stem cell-derived exosomes mediates cardioprotection in myocardial infarction by enhanced angiogenesis[J].Stem Cell Res Ther,2020;11(1):373.

88 Ni J,Liu X,Yin Y,et al.Exosomes derived from TIMP2-modified human umbilical cord mesenchymal stem cells enhance the repair effect in rat model with myocardial infarction possibly by the Akt/Sfrp2 pathway[J].Oxid Med Cell Longev,2019;2019:1958941.

89 Zhu W,Sun L,Zhao P,et al.Macrophage migration inhibitory factor facilitates the therapeutic efficacy of mesenchymal stem cells derived exosomes in acute myocardial infarction through upregulating miR-133a-3p[J].J Nanobiotechnol,2021;19(1):61.

90 Zheng H,Liang X,Han Q,et al.Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence[J].J Nanobiotechnol,2021;19(1):332.

91 Li S,Yang K,Cao W,et al.Tanshinone IIA enhances the therapeutic efficacy of mesenchymal stem cells derived exosomes in myocardial ischemia/reperfusion injury via up-regulating miR-223-5p[J].J Control Release,2023;358:13-26.

92 Zou Y,Li L,Li Y,et al.Restoring cardiac functions after myocardial infarction-ischemia/reperfusion via an exosome anchoring conductive hydrogel[J].ACS Appl Mater Interfaces,2021;13(48):56892-908.